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Drosophila melanogasterGenAge entry for Sir2 (Drosophila melanogaster)

Gene information (ID: 605)

Symbol
Sir2
Aliases
BEST:LD38188; CG5216; D.mel1; Dmel\CG5216; dmSRT406; ds
Name
CG5216-PA
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
NAD(+)-dependent histone deacetylase that silences gene expression

Potential relevance to longevity and/or ageing

Observations
Moderate (3-fold) Sir2 overexpression in the fat body during adulthood only can promote longevity in both sexes by roughly 13%.
% change in avg or median lifespan
Average lifespan is 13% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Overexpression of dSir2 did not result in increased lifespan when using the appropriate transgenic controls.
    Lifespan Effect
    Noeffect
    Longevity Category
    Not Recorded
    Primary reference
      Observations
      Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons (10-30% median lifespan reduction) and ubiquitous silencing of the Sir2-like genes shortened lifespans. The effects were severer at 28 C than at 25 C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of lifespan in Drosophila.
      % change in avg or median lifespan
      Median lifespan is 10-30% higher.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference
        Observations
        Overexpression of dSir2 extends lifespan by up to 57%, whereas a decrease in dSir2 blocks the life-extending effect of caloric reduction or rpd3 mutations.
        % change in avg or median lifespan
        Lifespan is up to 57% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Overexpression
        Longevity Category
        Pro-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
          • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
          • A homolog of this gene for Mus musculus is present as Sirt1
          • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as SIRT1
          GenDR gene manipulations
          • This gene is present as Sir2
          • A homolog of this gene for Mus musculus is present as Sirt1
          • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
          • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
          • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as SIRT1
          CellAge
          • A homolog of this gene for Homo sapiens is present as SIRT1

          Homologs in other organisms

          Caenorhabditis elegans
          sir-2.1
          Danio rerio
          sirt1
          Homo sapiens
          SIRT1
          Mus musculus
          Sirt1
          Rattus norvegicus
          Sirt1
          Saccharomyces cerevisiae
          SIR2
          Saccharomyces cerevisiae
          HST1

          External links

          FlyBase
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          Ensembl
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          Entrez Gene
          View on Entrez Gene database (34708)
          Homologues
          Search HomoloGene
          UniProt
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          Internet
          Search Google or Search Google Scholar