GenDR Dietary Restriction Gene Manipulation: Sir2
Gene Information (Entrez Gene ID: 34708)
- Symbol
- Sir2
- Aliases
- BEST:LD38188 CG5216 D.mel1 Dmel\CG5216 dmSRT406 dsir2 dSir2 dSIR2 DSir2 l(2)05326 sir2 SIR2 Sir2L
- Name
- Protein Sir2
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 34708
Potential relevance to dietary restriction and ageing
- Observations
-
Overexpression of Sir2 (alias dSir2) extends lifespan by up to 57% and specifically median lifespan by 40-60%, whereas a decrease in Sir2 activity by mutation blocks the life-extending effect of DR. Sir2 mutation does not reduce lifespan under ad libitum [1284]. Another study also found that whole-body Sir2 knockdown suppressed the life-extending effects of DR; moreover, Sir2 knockdown in the fat body resulted in suppression of life-extension under yeast-restricted conditions but normal lifespan under normal diet [2622].
- References
-
In other databases
- GenAge model organism genes
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SIRT1
- GenDR gene manipulations
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SIRT1
- CellAge
- A homolog of this gene for Homo sapiens is present as SIRT1
Homologs
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt1
- Homo sapiens
- SIRT1
- Mus musculus
- Sirt1
- Rattus norvegicus
- Sirt1
- Saccharomyces cerevisiae
- SIR2
- Saccharomyces cerevisiae
- HST1
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 34708
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar