Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Sir2

Gene Information (Entrez Gene ID: 34708)

Symbol
Sir2
Aliases
BEST:LD38188 CG5216 D.mel1 Dmel\CG5216 dmSRT406 dsir2 dSir2 dSIR2 DSir2 l(2)05326 sir2 SIR2 Sir2L
Name
Protein Sir2
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
34708

Potential relevance to dietary restriction and ageing

Observations

Overexpression of Sir2 (alias dSir2) extends lifespan by up to 57% and specifically median lifespan by 40-60%, whereas a decrease in Sir2 activity by mutation blocks the life-extending effect of DR. Sir2 mutation does not reduce lifespan under ad libitum [1284]. Another study also found that whole-body Sir2 knockdown suppressed the life-extending effects of DR; moreover, Sir2 knockdown in the fat body resulted in suppression of life-extension under yeast-restricted conditions but normal lifespan under normal diet [2622].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • This gene is present as Sir2
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
    • A homolog of this gene for Mus musculus is present as Sirt1
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as SIRT1
    GenDR gene manipulations
    • A homolog of this gene for Mus musculus is present as Sirt1
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
    • A homolog of this gene for Saccharomyces cerevisiae is present as HST1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SIRT1
    CellAge
    • A homolog of this gene for Homo sapiens is present as SIRT1

    Homologs

    Caenorhabditis elegans
    sir-2.1
    Danio rerio
    sirt1
    Homo sapiens
    SIRT1
    Mus musculus
    Sirt1
    Rattus norvegicus
    Sirt1
    Saccharomyces cerevisiae
    SIR2
    Saccharomyces cerevisiae
    HST1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 34708
    Homologues
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    UniProt
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    Internet
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