LongevityMap Gene

Gene details

HGNC symbol: RICTOR
Aliases: PIA; AVO3; hAVO3
Common name: RPTOR independent companion of MTOR complex 2
Description: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Cytogenetic Location: 5p13.1
UCSC Genome Browser: View 5p13.1 on the UCSC genome browser
OMIM: 609022
Ensembl: ENSG00000164327
UniProt/Swiss-Prot: RICTR_HUMAN
Entrez Gene: 253260
UniGene: 407926
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: rict-1
Danio rerio: rictorb
Danio rerio: rictora
Drosophila melanogaster: rictor
Mus musculus: Rictor
Rattus norvegicus: Rictor
Saccharomyces cerevisiae: TSC11
Schizosaccharomyces pombe: ste16

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Rictor
A homolog of this gene for Caenorhabditis elegans is present as rict-1

GenAge human genes

This gene is present as RICTOR

GenAge microarray genes

This gene is present as RICTOR

Studies (2)

Significant/Non-significant: 1/1

Study 1

Longevity Association

Population

Study Design

1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls

Conclusions

As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing

Indentifier

Reference

Study 2

Longevity Association: Non-significant
Population: American of Japanese origin
Study Design: 81 tagSNPs that provided virtually complete coverage of key mTOR genes complex genes MTOR, RPTOR, and RICTOR, as well as RPS6KA1, were tested in 814 males (440 aged 95 years and older, 374 controls) for association with longevity and health span phenotypes.
Conclusions: No association was found between genotypes and longevity or aging-related biologic, clinical or functional phenoypes after mutiple test correction.
Indentifier