GenAge entry for MIF (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 290)

HGNC symbol: MIF
Aliases: GIF; GLIF
Common name: macrophage migration inhibitory factor (glycosylation-inhibiting factor)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: MIF is involved in several processes, including in cell proliferation and inflammation. Its levels are elevated in long-lived mouse models, including in caloric restriction. Knocking out MIF in mice results in an extended lifespan (knockout mice live 16% longer than controls) and are even longer-lived under caloric restriction [3248]. These results suggest a potential role in ageing, though human studies are lacking.

Cytogenetic information

Cytogenetic band: 22q11.23
Location: 23,894,378 bp to 23,895,222 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001516; prostaglandin biosynthetic process
GO:0002906; negative regulation of mature B cell apoptotic process
GO:0006954; inflammatory response
GO:0007166; cell surface receptor signaling pathway
GO:0007569; cell aging
GO:0008283; cell proliferation
GO:0010629; negative regulation of gene expression
GO:0010739; positive regulation of protein kinase A signaling
GO:0019752; carboxylic acid metabolic process
GO:0030330; DNA damage response, signal transduction by p53 class mediator
GO:0030890; positive regulation of B cell proliferation

And 25 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0009986; cell surface
GO:0031982; vesicle
GO:0043209; myelin sheath
GO:0070062; extracellular exosome

Function:

GO:0004167; dopachrome isomerase activity
GO:0005102; receptor binding
GO:0005125; cytokine activity
GO:0005126; cytokine receptor binding
GO:0005515; protein binding
GO:0042056; chemoattractant activity
GO:0050178; phenylpyruvate tautomerase activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, HSP90AA1, PCMT1, STUB1, MIF
STRING interaction network

Retrieve sequences for MIF

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: mif-1
Danio rerio: mif
Mus musculus: Mif
Rattus norvegicus: LOC679748
Rattus norvegicus: AABR07059201.1
Rattus norvegicus: LOC103694877
Rattus norvegicus: Mif
Rattus norvegicus: Mif
Rattus norvegicus: LOC103694877
Rattus norvegicus: RGD1560513
Rattus norvegicus: RGD1565459
Rattus norvegicus: AABR07016805.1
Rattus norvegicus: RGD1559921

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Mif

CellAge

This gene is present as MIF