Caenorhabditis elegansGenAge entry for cco-1 (Caenorhabditis elegans)

Gene information (ID: 95)

Symbol
cco-1
Name
Cytochrome C Oxidase
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Electron transport

Potential relevance to longevity and/or ageing

Observations
RNA interference extends lifespan.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNAi resulted in a lifespan extension.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      RNAi resulted in a 45-61% increase in mean lifespan.
      % change in avg or median lifespan
      Average lifespan is 45-61% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Extended mean lifespan (30-80% in different backgrounds) when inactivated post developmentally.
        % change in avg or median lifespan
        Average lifespan is 30-80% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          RNAi resulted in a 20% extendned mean lifespan.
          % change in avg or median lifespan
          Average lifespan is 20% higher.
          Lifespan Effect
          Increase
          Genetic Manipulation
          RNA interference
          Longevity Category
          Anti-Longevity
          Primary reference

            In other databases

            GenDR gene manipulations
            • A homolog of this gene for Drosophila melanogaster is present as CoVb
            CellAge
            • A homolog of this gene for Homo sapiens is present as COX5B

            Homologs in other organisms

            Danio rerio
            cox5b2
            Danio rerio
            COX5B (1 of many)
            Danio rerio
            COX5B (1 of many)
            Drosophila melanogaster
            CoVb
            Homo sapiens
            COX5B
            Mus musculus
            Gm11273
            Mus musculus
            Cox5b
            Rattus norvegicus
            AC096404.1
            Rattus norvegicus
            Cox5b
            Schizosaccharomyces pombe
            cox4

            External links

            WormBase
            Search
            Ensembl
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            Entrez Gene
            View on Entrez Gene database (172832)
            Homologues
            Search HomoloGene
            UniProt
            Search
            Internet
            Search Google or Search Google Scholar