GenAge entry for Tpp2 (Mus musculus)
Gene information (ID: 829)
- Symbol
- Tpp2
- Aliases
- TPP-2; TppII
- Name
- Tripeptidyl peptidase II
- Organism
- Mus musculus (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Young KO mice are viable and grossly indistinguishable from WT littermates. Over 1 year of age KO mice show elevated mortality associated with aged appearance, disheveled fur, large bald areas, reduced body mass, and loss of vigor. Mice also show symptoms characteristic of immunohematopoietic senescence, including accelerated thymic involution, lymphopenia, impaired proliferative T cell responses, extramedullary hematopoiesis, and inflammation.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as TPP2
Homologs in other organisms
- Caenorhabditis elegans
- tpp-2
- Danio rerio
- TPP2
- Drosophila melanogaster
- TppII
- Homo sapiens
- TPP2
- Rattus norvegicus
- Tpp2
- Schizosaccharomyces pombe
- tpp2
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (22019)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar