GenAge entry for Ire1 (Drosophila melanogaster)
Gene information (ID: 2148)
- Symbol
- Ire1
- Name
- Inositol-requiring enzyme-1
- Organism
- Drosophila melanogaster (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Whole body depletion of Ire1 using RNA interference reduced the lifespan of flies and negated the lifespan extending effects of dietary restriction. This effect was found to be tissue specific, Ire1 expression in the midgut is required for starvation tolerance and lifespan extension.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as ire-1
- GenDR gene manipulations
Homologs in other organisms
External links
- FlyBase
- Search
- Ensembl
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- Entrez Gene
- View on Entrez Gene database (42358)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar