- Symbol
- Lmna
- Aliases
- Dhe
- Name
- lamin A
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- LMNA encodes components of the lamina
- Observations
- The Lmna "progeria" allele (G690G), obtained through a mutation responsible for an increased ratio of Progerin/Lamin A, results in shorter mice lifespan compared to wild-type. For the heterozygous mice, median lifespan is reduced by ~40%, while the homozygous mice live about 83% lower.
- % change in avg or median lifespan
- Median lifespan is up to 83% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- The Lmna LCS, a knock-in mutation responsible for specifically not-producing Progerin, results in an increased lifespan. For the heterozygous mutation, median lifespan is extended by ~13%, while for the homozygous mutation median lifespan is ~10% longer.
- % change in avg or median lifespan
- Median lifespan is up to 13% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Homozygous mice display signs of premature ageing, including a marked reduction in growth rate and death by 4 weeks of age.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as lmn-1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as LMNA
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as LMNA
- LongevityMap
- A homolog of this gene for Homo sapiens is present as LMNA
- CellAge
- A homolog of this gene for Homo sapiens is present as LMNA
- Caenorhabditis elegans
- lmn-1
- Danio rerio
- lmna
- Drosophila melanogaster
- LamC
- Drosophila melanogaster
- Lam
- Homo sapiens
- LMNA
- Rattus norvegicus
- Lmna
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (16905)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar