Mus musculusGenAge entry for Ikbkb (Mus musculus)

Gene information (ID: 1811)

Symbol
Ikbkb
Aliases
IKK2; IKK-2; IKK[b]; IKKbeta; AI132552; IKK-beta
Name
inhibitor of kappaB kinase beta
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Brain-specific knockout mice live 23% longer. Moreover, viral activation in the hypothalamus activated NFkB and reduced lifespan.
% change in avg or median lifespan
Average lifespan is 23% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as ATG1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as IKBKB
    GenDR gene manipulations
    • A homolog of this gene for Saccharomyces cerevisiae is present as ATG1

    Homologs in other organisms

    Caenorhabditis elegans
    T07F12.4
    Danio rerio
    ikbkb
    Drosophila melanogaster
    ird5
    Homo sapiens
    IKBKB
    Rattus norvegicus
    Ikbkb
    Saccharomyces cerevisiae
    ATG1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (16150)
    Homologues
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    UniProt
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    Internet
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