Caenorhabditis elegansGenAge entry for ifg-1 (Caenorhabditis elegans)

Gene information (ID: 362)

Symbol
ifg-1
Name
Initiation Factor 4G (eIF4G) family
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
A scaffold protein for translation initiation factors

Potential relevance to longevity and/or ageing

Observations
Post developmental RNAi resulted in a mean and maximum lifespan daf-16 dependent extension.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNAi increased maximum lifespan by about 30%. Reducing the levels of eIF2B or eIF4G did not extend the lifespan of daf-16 mutants at all. eIF2B and eIF4G RNAi slightly shortened the lifespan of daf-2 mutants. sir-2.1 deletion mutant was subjected to sir-2.1(ok434), to RP, S6K, TOR or eIF RNAi; In each case, lifespan was extended.
    % change in max lifespan
    Maximum lifespan is 30% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Inhibition of ifg-1 during adulthood led to a 36% increase in maximum lifespan. Inhibition of at least one eIF4E isoform and two of the three poly(A)-binding proteins also has a significant effect on lifespan extension. Inhibition of let-363 increased lifespan in both the N2 background and when ifg-1 was inhibited. In the daf-2 (e1370) mutant background, inhibition of either ifg-1 or rsks-1 further extended lifespan by 70% and 24%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan by 27% and 14%, respectively, in a daf-16 (mu86 ) background. Inhibition of either ifg-1 or rsks-1 in the clk-1(e2519) mutant background led to a further lifespan extension by 19% and 13%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan in the eat-2 background by 54% and 11%, respectively. In a sir-2.1 mutant background, ifg-1 inhibition extended lifespan by 93% and rsks-1 inhibition by 33%.
      % change in max lifespan
      Maximum lifespan is 36% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      RNA interference
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        RNA interference in adulthood resulted in a 55% mean lifespan extension.
        % change in avg or median lifespan
        Average lifespan is 55% higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        RNA interference
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          RNAi resulted in a 30% maximum lifespan extension compared to wild-type.
          % change in max lifespan
          Maximum lifespan is 30% higher.
          Lifespan Effect
          Increase
          Genetic Manipulation
          RNA interference
          Longevity Category
          Anti-Longevity
          Primary reference

            In other databases

            GenAge model organism genes
            • A homolog of this gene for Saccharomyces cerevisiae is present as TIF4631
            • A homolog of this gene for Saccharomyces cerevisiae is present as TIF4632

            Homologs in other organisms

            Danio rerio
            eif4g3b
            Danio rerio
            eif4g1a
            Danio rerio
            CABZ01085052.1
            Danio rerio
            eif4g3a
            Drosophila melanogaster
            eIF4G2
            Drosophila melanogaster
            eIF4G
            Homo sapiens
            EIF4G3
            Homo sapiens
            EIF4G1
            Mus musculus
            Eif4g3
            Mus musculus
            Eif4g1
            Rattus norvegicus
            LOC100912571
            Rattus norvegicus
            Eif4g1
            Rattus norvegicus
            Eif4g3
            Saccharomyces cerevisiae
            TIF4631
            Saccharomyces cerevisiae
            TIF4632
            Schizosaccharomyces pombe
            tif471

            External links

            WormBase
            Search
            Ensembl
            Search
            Entrez Gene
            View on Entrez Gene database (174322)
            Homologues
            Search HomoloGene
            UniProt
            Search
            Internet
            Search Google or Search Google Scholar