Caenorhabditis elegansGenAge entry for skr-1 (Caenorhabditis elegans)

Gene information (ID: 613)

Symbol
skr-1
Name
SKp1 Related (ubiquitin ligase complex component)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
SKp1 Related (ubiquitin ligase complex component)

Potential relevance to longevity and/or ageing

Observations
RNA interference in adulthood of skr-1 and skr-2 shortened the extended lifespan of daf-2(mu150) mutants by up to 44%. No effect in the lifespan of wild-type worms or in the extended lifespans of glp-1(e2141ts) or eat-2(ad1116) mutants was observed.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    skp1
    Drosophila melanogaster
    SkpB
    Drosophila melanogaster
    SkpF
    Drosophila melanogaster
    SkpE
    Drosophila melanogaster
    SkpC
    Drosophila melanogaster
    SkpA
    Drosophila melanogaster
    SkpD
    Homo sapiens
    0
    Homo sapiens
    SKP1
    Mus musculus
    Skp1a
    Rattus norvegicus
    Skp1
    Saccharomyces cerevisiae
    SKP1

    External links

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    Entrez Gene
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    Internet
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