Caenorhabditis elegansGenAge entry for inf-1 (Caenorhabditis elegans)

Gene information (ID: 367)

Symbol
inf-1
Name
INitiation Factor
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Scaffold protein for translation initiation factors

Potential relevance to longevity and/or ageing

Observations
RNA interference of inf-1 results in an increased lifespan.
% change in avg or median lifespan
Mean lifespan is 21.4% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference
Longevity Category
Anti-Longevity
Primary reference
    Observations
    RNA interference in adulthood resulted in a up to 46% mean lifespan extension.
    % change in avg or median lifespan
    Average lifespan is up to 46% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    RNA interference
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Post developmental RNAi resulted in a 10% mean lifespan reduction.
      % change in avg or median lifespan
      Average lifespan is 10% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Saccharomyces cerevisiae is present as TIF1

        Homologs in other organisms

        Danio rerio
        eif4a2
        Drosophila melanogaster
        eIF-4a
        Homo sapiens
        EIF4A1
        Mus musculus
        Eif4a1
        Rattus norvegicus
        Eif4a1
        Saccharomyces cerevisiae
        TIF1
        Schizosaccharomyces pombe
        tif1

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (175966)
        Homologues
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        UniProt
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        Internet
        Search Google or Search Google Scholar