Caenorhabditis elegansGenAge entry for ifta-2 (Caenorhabditis elegans)

Gene information (ID: 363)

Symbol
ifta-2
Name
IntraFlagellar Transport Associated
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Ciliar protein

Potential relevance to longevity and/or ageing

Observations
Knockouts have an extended lifespan phenotype (40-50%) and are defective in dauer formation due to defects in daf-2 receptor signalling pathway in ciliatedsensory neurons. There was no additive effect of the ifta-2 mutation on the daf-2 longevity phenotype.
% change in avg or median lifespan
Lifespan is 40-50% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    rabl5
    Homo sapiens
    RABL5
    Mus musculus
    Rabl5
    Rattus norvegicus
    Rabl5

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (189055)
    Homologues
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    UniProt
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    Internet
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