Caenorhabditis elegansGenAge entry for daf-4 (Caenorhabditis elegans)

Gene information (ID: 166)

Symbol
daf-4
Name
abnormal DAuer Formation
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Encodes a transmembrane serine/threonine kinase

Potential relevance to longevity and/or ageing

Observations
Mutation in adults increased mean lifespan by up to 120% and maximum lifespan by up to 185%.
% change in max lifespan
Maximum lifespan is up to 185% higher.
% change in avg or median lifespan
Average lifespan is up to 120% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    si:dkey-101k6.5
    Drosophila melanogaster
    wit
    Homo sapiens
    TGFBR2
    Mus musculus
    Tgfbr2
    Rattus norvegicus
    Tgfbr2

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (175781)
    Homologues
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    UniProt
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    Internet
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