Caenorhabditis elegansGenAge entry for daf-2 (Caenorhabditis elegans)

Gene information (ID: 163)

Symbol
daf-2
Name
abnormal DAuer Formation DAF-2, fork head-related transcription factor (daf-2)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Insulin receptor homolog, regulator of dauer formation

Potential relevance to longevity and/or ageing

Observations
Mutations in the daf-2 gene double adult lifespan.
% change in avg or median lifespan
Lifespan is two-fold higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutations
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Mutants live more than twice as long as controls. This lifespan extension requires the activity of daf-16.
    % change in avg or median lifespan
    Lifespan is more than twice higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Mutants show increased lifespan.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Mutations
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Mutants show a two-fold increase in lifespan.
        % change in avg or median lifespan
        Lifespan is two-fold higher.
        Lifespan Effect
        Increase
        Genetic Manipulation
        Germline ablation in daf-2 mutants
        Longevity Category
        Anti-Longevity
        Primary reference
          Observations
          Mutants show a 2-3 fold increase in lifespan.
          % change in avg or median lifespan
          Lifespan is two-three folds higher.
          Lifespan Effect
          Increase
          Genetic Manipulation
          Mutations
          Longevity Category
          Anti-Longevity
          Primary reference
            Observations
            RNAi resulted in a 17-22% increase in mean lifespan.
            % change in avg or median lifespan
            Average lifespan is 17-22% higher.
            Lifespan Effect
            Increase
            Genetic Manipulation
            RNA interference
            Longevity Category
            Anti-Longevity
            Primary reference
              Observations
              Post developmental RNAi resulted in a 79% increase in mean lifespan.
              % change in avg or median lifespan
              Average lifespan is 79% higher.
              Lifespan Effect
              Increase
              Genetic Manipulation
              RNA interference
              Longevity Category
              Anti-Longevity
              Primary reference

                In other databases

                GenAge model organism genes
                • A homolog of this gene for Drosophila melanogaster is present as InR
                GenDR gene manipulations
                • A homolog of this gene for Drosophila melanogaster is present as InR
                • This gene is present as daf-2

                Homologs in other organisms

                Danio rerio
                insrb
                Drosophila melanogaster
                InR
                Homo sapiens
                INSRR
                Mus musculus
                Insrr
                Rattus norvegicus
                Insrr

                External links

                WormBase
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                Ensembl
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                Entrez Gene
                View on Entrez Gene database (175410)
                Homologues
                Search HomoloGene
                UniProt
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                Internet
                Search Google or Search Google Scholar