Caenorhabditis elegansGenAge entry for cul-1 (Caenorhabditis elegans)

Gene information (ID: 143)

Symbol
cul-1
Name
CULlin
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Scaffolding protein

Potential relevance to longevity and/or ageing

Observations
RNAi decreased lifespan of daf-2 mutant, but not of WT or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signalling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO.
Lifespan Effect
Decrease
Genetic Manipulation
RNA interference
Longevity Category
Pro-Longevity
Primary reference

    Homologs in other organisms

    Danio rerio
    cul1b
    Homo sapiens
    CUL1
    Mus musculus
    Cul1
    Rattus norvegicus
    Cul1

    External links

    WormBase
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    Entrez Gene
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    Homologues
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    UniProt
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    Internet
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