GenAge entry for Neil1 (Mus musculus)
Gene information (ID: 458)
- Symbol
- Neil1
- Aliases
- Nei1; 2810450N13Rik
- Name
- nei endonuclease VIII-like 1 (E. coli)
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Base excision repair of ring-fragmented purines and some saturated pyrimidines
Potential relevance to longevity and/or ageing
- Observations
- Knockout mice develop severe obesity, dyslipidemia, fatty liver disease, increased levels of DNA damage in the mtDNA, and have a tendency to develop hyperinsulinemia.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
Homologs in other organisms
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (72774)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar