LongevityMap variant group

Entry Details

Longevity Association
Non-significant
Population
Italian (Southern)
Study Design
Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
Conclusions
None of the tested single nucleotide polymorphisms, excepting rs978739, showed a significant association with the longevity phenotype

Variants (38)

No gene

1.
Identifier
rs41467
Cytogenetic Location
2.
Identifier
rs534126
Cytogenetic Location
3.
Identifier
rs2588350
Cytogenetic Location

PRH1

1.
Identifier
rs11610105
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
2.
Identifier
rs3741843
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
3.
Identifier
rs3916060
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
4.
Identifier
rs10772397
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
5.
Identifier
rs1376251
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
6.
Identifier
rs6488334
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
7.
Identifier
rs10772420
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
8.
Identifier
rs10845293
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
9.
Identifier
rs10845296
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
10.
Identifier
rs12370363
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
11.
Identifier
rs2708380
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
12.
Identifier
rs2708381
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser

Gene details

HGNC symbol
PRH1
Aliases
PA; Db-s; PRH2; PIF-S; Pr1/Pr2 
Common name
proline rich protein HaeIII subfamily 1 
Description
This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Other longevity studies of this gene
11
OMIM
168730
Ensembl
ENSG00000231887
UniProt/Swiss-Prot
A0A087WV42_HUMAN
Entrez Gene
5554
UniGene
656965
HapMap
View on HapMap

Homologs in model organisms

No homologs found

TAS2R1

1.
Identifier
rs2234233
Cytogenetic Location
5p15.31
UCSC Genome Browser
View 5p15.31 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R1
Aliases
T2R1; TRB7 
Common name
taste 2 receptor member 1 
Description
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
OMIM
604796
Ensembl
ENSG00000169777
UniProt/Swiss-Prot
Q502V6_HUMAN
Entrez Gene
50834
UniGene
567492
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r119
Rattus norvegicus
Tas2r119

TAS2R16

1.
Identifier
rs1357949
Cytogenetic Location
7q31.32
UCSC Genome Browser
View 7q31.32 on the UCSC genome browser
2.
Identifier
rs6466849
Cytogenetic Location
7q31.32
UCSC Genome Browser
View 7q31.32 on the UCSC genome browser
3.
Identifier
rs860170
Cytogenetic Location
7q31.32
UCSC Genome Browser
View 7q31.32 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R16
Aliases
T2R16 
Common name
taste 2 receptor member 16 
Description
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
3
OMIM
604867
Ensembl
ENSG00000128519
UniProt/Swiss-Prot
T2R16_HUMAN
Entrez Gene
50833
UniGene
272395
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r118
Rattus norvegicus
Tas2r118

TAS2R20

1.
Identifier
rs7135018
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
2.
Identifier
rs7301234
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser
3.
Identifier
rs10772408
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R20
Aliases
T2R20; T2R49; T2R56; TAS2R49 
Common name
taste 2 receptor member 20 
Description
This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016]
Other longevity studies of this gene
2
OMIM
613962
Ensembl
ENSG00000255837
UniProt/Swiss-Prot
T2R20_HUMAN
Entrez Gene
259295
UniGene
686384
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r136
Mus musculus
Tas2r120
Rattus norvegicus
Tas2r136
Rattus norvegicus
Tas2r120

TAS2R3

1.
Identifier
rs11763979
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R3
Aliases
T2R3 
Common name
taste 2 receptor member 3 
Description
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
OMIM
604868
Ensembl
ENSG00000127362
UniProt/Swiss-Prot
TA2R3_HUMAN
Entrez Gene
50831
UniGene
676011
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r137
Rattus norvegicus
Tas2r137

TAS2R30

1.
Identifier
rs2599404
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R30
Aliases
T2R30; T2R47; TAS2R47 
Common name
taste 2 receptor member 30 
Description
OMIM
613963
Ensembl
ENSG00000256188
UniProt/Swiss-Prot
T2R30_HUMAN
Entrez Gene
259293
UniGene
679464
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r136
Mus musculus
Tas2r120
Rattus norvegicus
Tas2r136
Rattus norvegicus
Tas2r120

TAS2R38

1.
Identifier
rs10246939
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser
2.
Identifier
rs1726866
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser
3.
Identifier
rs713598
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R38
Aliases
PTC; T2R38; T2R61 
Common name
taste 2 receptor member 38 
Description
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
Other longevity studies of this gene
2
OMIM
607751
Ensembl
ENSG00000257138
UniProt/Swiss-Prot
T2R38_HUMAN
Entrez Gene
5726
UniGene
647085
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r138
Rattus norvegicus
Tas2r138

TAS2R39

1.
Identifier
rs4726600
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R39
Aliases
T2R39; T2R57 
Common name
taste 2 receptor member 39 
Description
The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
OMIM
Ensembl
ENSG00000236398
UniProt/Swiss-Prot
T2R39_HUMAN
Entrez Gene
259285
UniGene
553660
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r139
Rattus norvegicus
Tas2r139

TAS2R4

1.
Identifier
rs2233998
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser
2.
Identifier
rs2234001
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R4
Aliases
T2R4 
Common name
taste 2 receptor member 4 
Description
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene
1
OMIM
604869
Ensembl
ENSG00000127364
UniProt/Swiss-Prot
TA2R4_HUMAN
Entrez Gene
50832
UniGene
735690
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r108
Rattus norvegicus
Tas2r108

TAS2R40

1.
Identifier
rs10260248
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R40
Aliases
GPR60; T2R40; T2R58 
Common name
taste 2 receptor member 40 
Description
OMIM
613964
Ensembl
ENSG00000221937
UniProt/Swiss-Prot
T2R40_HUMAN
Entrez Gene
259286
UniGene
352241
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r144
Rattus norvegicus
Tas2r144

TAS2R41

1.
Identifier
rs1404635
Cytogenetic Location
7q35
UCSC Genome Browser
View 7q35 on the UCSC genome browser
2.
Identifier
rs10278721
Cytogenetic Location
7q35
UCSC Genome Browser
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Gene details

HGNC symbol
TAS2R41
Aliases
T2R41; T2R59 
Common name
taste 2 receptor member 41 
Description
Other longevity studies of this gene
1
OMIM
613965
Ensembl
ENSG00000221855
UniProt/Swiss-Prot
T2R41_HUMAN
Entrez Gene
259287
UniGene
650648
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r126
Rattus norvegicus
Tas2r126

TAS2R42

1.
Identifier
rs5020531
Cytogenetic Location
12p13.2
UCSC Genome Browser
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Gene details

HGNC symbol
TAS2R42
Aliases
T2R24; T2R42; T2R55; TAS2R55 
Common name
taste 2 receptor member 42 
Description
OMIM
613966
Ensembl
ENSG00000186136
UniProt/Swiss-Prot
A0A0G2JPZ2_HUMAN
Entrez Gene
353164
UniGene
553716
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r131
Rattus norvegicus
Tas2r145

TAS2R5

1.
Identifier
rs2227264
Cytogenetic Location
7q34
UCSC Genome Browser
View 7q34 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R5
Aliases
T2R5 
Common name
taste 2 receptor member 5 
Description
This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
OMIM
605062
Ensembl
ENSG00000127366
UniProt/Swiss-Prot
A4D1U0_HUMAN
Entrez Gene
54429
UniGene
675370
HapMap
View on HapMap

Homologs in model organisms

No homologs found

TAS2R60

1.
Identifier
rs4595035
Cytogenetic Location
7q35
UCSC Genome Browser
View 7q35 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R60
Aliases
T2R56; T2R60 
Common name
taste 2 receptor member 60 
Description
OMIM
613968
Ensembl
ENSG00000185899
UniProt/Swiss-Prot
T2R60_HUMAN
Entrez Gene
338398
UniGene
688222
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r135
Rattus norvegicus
Tas2r135

TAS2R7

1.
Identifier
rs619381
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R7
Aliases
T2R7; TRB4 
Common name
taste 2 receptor member 7 
Description
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
OMIM
604793
Ensembl
ENSG00000121377
UniProt/Swiss-Prot
TA2R7_HUMAN
Entrez Gene
50837
UniGene
533754
HapMap
View on HapMap

Homologs in model organisms

Mus musculus
Tas2r130
Rattus norvegicus
Tas2r130

TAS2R9

1.
Identifier
rs3741845
Cytogenetic Location
12p13.2
UCSC Genome Browser
View 12p13.2 on the UCSC genome browser

Gene details

HGNC symbol
TAS2R9
Aliases
T2R9; TRB6 
Common name
taste 2 receptor member 9 
Description
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
OMIM
604795
Ensembl
ENSG00000121381
UniProt/Swiss-Prot
TA2R9_HUMAN
Entrez Gene
50835
UniGene
272391
HapMap
View on HapMap

Homologs in model organisms

No homologs found

References

Campa et al. (2012)

Other variants which are also part of this study