LongevityMap Gene

Gene details

HGNC symbol: TAS2R16
Aliases: T2R16
Common name: taste 2 receptor member 16
Description: This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 7q31.32
UCSC Genome Browser: View 7q31.32 on the UCSC genome browser
OMIM: 604867
Ensembl: ENSG00000128519
UniProt/Swiss-Prot: T2R16_HUMAN
Entrez Gene: 50833
UniGene: 272395
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/1

Longevity Association: Significant
Population: Italian (Southern)
Study Design: Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
Conclusions: One of the analyzed polymorphism, rs978739, situated upstream of the TAS2R16 gene, shows a statistically significant association with longevity. The frequency of A/A homozygotes increases gradually from 35% in subjects aged 20 to 70 up to 55% in centenarians.
Indentifier

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
Conclusions: None of the tested single nucleotide polymorphisms, excepting rs978739, showed a significant association with the longevity phenotype
Indentifier