LongevityMap Gene
Gene details
- HGNC symbol
- PRH1
- Aliases
- PA; Db-s; PRH2; PIF-S; Pr1/Pr2
- Common name
- proline rich protein HaeIII subfamily 1
- Description
- This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
- Cytogenetic Location
- 12p13.2
- UCSC Genome Browser
- View 12p13.2 on the UCSC genome browser
- OMIM
- 168730
- Ensembl
- ENSG00000231887
- UniProt/Swiss-Prot
- A0A087WV42_HUMAN
- Entrez Gene
- 5554
- UniGene
- 656965
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
No homologs found
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs978739, showed a significant association with the longevity phenotype
- Indentifier
- rs11610105
- Reference