LongevityMap Gene
Gene details
- HGNC symbol
- TAS2R39
- Aliases
- T2R39; T2R57
- Common name
- taste 2 receptor member 39
- Description
- The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
- Cytogenetic Location
- 7q34
- UCSC Genome Browser
- View 7q34 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000236398
- UniProt/Swiss-Prot
- T2R39_HUMAN
- Entrez Gene
- 259285
- UniGene
- 553660
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs978739, showed a significant association with the longevity phenotype
- Indentifier
- rs4726600
- Reference