LongevityMap Gene
Gene details
- HGNC symbol
- TAS2R9
- Aliases
- T2R9; TRB6
- Common name
- taste 2 receptor member 9
- Description
- This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 12p13.2
- UCSC Genome Browser
- View 12p13.2 on the UCSC genome browser
- OMIM
- 604795
- Ensembl
- ENSG00000121381
- UniProt/Swiss-Prot
- TA2R9_HUMAN
- Entrez Gene
- 50835
- UniGene
- 272391
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
No homologs found
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs978739, showed a significant association with the longevity phenotype
- Indentifier
- rs3741845
- Reference