- Symbol
- pcm-1
- Name
- Protein Carboxymethyltransferase
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Overexpression of PCM-1 increases mean adult hermaphrodite life span by 30%. Dauer larvae with a deletion in the pcm-1 gene had a median life span only one quarter of the wt dauer life span at 20C. pcm-1 mutant larvae respond poorly to a pheromone signal as indicated by the reduced number of dauer larvae formed.
- % change in avg or median lifespan
- Average lifespan is 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression, mutations, deletion
- Longevity Category
- Pro-Longevity
- Primary reference
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- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Pcmt
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PCMT1
- Danio rerio
- pcmtl
- Danio rerio
- pcmt
- Drosophila melanogaster
- Pcmt
- Homo sapiens
- PCMT1
- Mus musculus
- Pcmt1
- Rattus norvegicus
- Pcmt1
- Schizosaccharomyces pombe
- pcm2
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (178981)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for pcm-1 (Caenorhabditis elegans)