Saccharomyces cerevisiaeGenAge entry for TOR1 (Saccharomyces cerevisiae)

Gene information (ID: 679)

Symbol
TOR1
Aliases
DRR1
Name
PIK-related protein kinase and rapamycin target
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Subunit of TORC1, a complex that controls growth in response to nutrients

Potential relevance to longevity and/or ageing

Observations
Deletion increased mean and maximum lifespan by 20%.
% change in max lifespan
Maximum lifespan is 20% higher.
% change in avg or median lifespan
Average lifespan is 20% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference
    Observations
    Deletion of TOR1 substantially extended chronological life span, increasing median survival almost 3-fold (wild-type 4.5 days, tor1 null 12 days). By 21 days in culture, the vast majority of wild-type cells had died (>99.9%), whereas many tor1 null cells remained viable. Deletion of TOR1 also extended the chronological life span of the relatively short-lived strain BY4742, one of the two haploid genetic backgrounds of the widely used Yeast Knockout Collection available from Open Biosystems. Deletion of TOR1 fails to extendLS in Petite strains that are unable to respire
    Lifespan Effect
    Increase
    Genetic Manipulation
    Deletion
    Longevity Category
    Anti-Longevity
    Primary reference
      Observations
      Replicative lifespan increased by 30% in the alpha strain and 20% in a strain
      % change in avg or median lifespan
      Replicative lifespan is 20-30% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Deletion
      Longevity Category
      Anti-Longevity
      Primary reference
        Observations
        Mean chronological lifespan strongly increased in the a strain
        Lifespan Effect
        Increase
        Genetic Manipulation
        Deletion
        Longevity Category
        Anti-Longevity
        Primary reference

          In other databases

          GenAge model organism genes
          • A homolog of this gene for Caenorhabditis elegans is present as let-363
          • A homolog of this gene for Drosophila melanogaster is present as Tor
          • A homolog of this gene for Caenorhabditis elegans is present as smg-1
          • A homolog of this gene for Mus musculus is present as Mtor
          GenAge human genes
          • A homolog of this gene for Homo sapiens is present as MTOR
          GenDR gene manipulations
          • A homolog of this gene for Caenorhabditis elegans is present as let-363
          • This gene is present as TOR1
          LongevityMap
          • A homolog of this gene for Homo sapiens is present as MTOR
          CellAge
          • A homolog of this gene for Homo sapiens is present as SMG1

          Homologs in other organisms

          Caenorhabditis elegans
          let-363
          Caenorhabditis elegans
          smg-1
          Danio rerio
          smg1
          Danio rerio
          mtor
          Drosophila melanogaster
          Tor
          Drosophila melanogaster
          nonC
          Homo sapiens
          SMG1
          Homo sapiens
          MTOR
          Mus musculus
          Mtor
          Mus musculus
          Smg1
          Rattus norvegicus
          Mtor
          Schizosaccharomyces pombe
          tor2

          External links

          Saccharomyces Genome Database
          Search
          Ensembl
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          Entrez Gene
          View on Entrez Gene database (853529)
          Homologues
          Search HomoloGene
          UniProt
          Search
          Internet
          Search Google or Search Google Scholar