Cell Senescence Entries for SMG1

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

SMG1 Gene Information

HGNC symbol
SMG1 
Aliases
ATX; KIAA0421; LIP 
Common name
SMG1 nonsense mediated mRNA decay associated PI3K related kinase 
Entrez Id
23049
Description
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013].

SMG1 Ontologies

Gene Ontology
Process: GO:184; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:16310; phosphorylation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:18105; peptidyl-serine phosphorylation
GO:6406; mRNA export from nucleus
GO:46777; protein autophosphorylation
GO:6468; protein phosphorylation
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:31929; TOR signaling
GO:2001020; regulation of response to DNA damage stimulus
And 5 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:33391; chromatoid body
GO:31931; TORC1 complex
GO:31932; TORC2 complex
Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4672; protein kinase activity
And 3 more GO terms
Show all GO terms

Homologs of SMG1 in Model Organisms

Caenorhabditis elegans
smg-1
Danio rerio
smg1
Drosophila melanogaster
nonC
Mus musculus
Smg1
Saccharomyces cerevisiae
TOR1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as TOR1
  • A homolog of this gene for Caenorhabditis elegans is present as smg-1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as TOR1

External links

OMIM
607032
Ensembl
ENSG00000157106
Entrez Gene
23049
UniGene
460179
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMG1
GeneCards
SMG1