GenDR Dietary Restriction Gene Manipulation: let-363
Gene Information (Entrez Gene ID: 172167)
Potential relevance to dietary restriction and ageing
let-363 RNAi significantly extends the lifespan of wild-type, but does not further extend the long lifespan of eat-2 mutant . let-363 RNAi led to an average increase in lifespan of 8% in wild-type and 3% in eat-2 background, suggesting let-363 works synergistically with eat-2 mutation . Another study showed that DR fails to significantly extend lifespan of let-363 RNAi-treated animals .
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as TOR1