Mus musculusGenAge entry for Rps6kb1 (Mus musculus)

Gene information (ID: 1737)

Symbol
Rps6kb1
Aliases
S6K1; 70kDa; p70s6k; AA959758; AI256796; AI314060; p70/8
Name
ribosomal protein S6 kinase, polypeptide 1
Organism
Mus musculus (AnAge)

Potential relevance to longevity and/or ageing

Observations
Deletion of ribosomal S6 protein kinase 1 (S6K1) induced gene expression patterns similar to those seen in caloric restriction and led to increased lifespan and resistance to age-related pathologies, such as bone, immune, motor dysfunction and loss of insulin sensitivity in female mice. No significant lifespan effect was observed in males.
% change in avg or median lifespan
Median female lifespan is 19% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as rsks-1
    • A homolog of this gene for Drosophila melanogaster is present as S6k
    • A homolog of this gene for Saccharomyces cerevisiae is present as TPK3
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as RPS6KB1

    Homologs in other organisms

    Caenorhabditis elegans
    rsks-1
    Danio rerio
    rps6kb1b
    Danio rerio
    rps6kb1a
    Drosophila melanogaster
    S6k
    Homo sapiens
    RPS6KB1
    Rattus norvegicus
    Rps6kb1
    Saccharomyces cerevisiae
    TPK3

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (72508)
    Homologues
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    UniProt
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    Internet
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