- Symbol
- Rps6kb1
- Aliases
- S6K1; 70kDa; p70s6k; AA959758; AI256796; AI314060; p70/8
- Name
- ribosomal protein S6 kinase, polypeptide 1
- Organism
- Mus musculus (AnAge)
- Observations
- Deletion of ribosomal S6 protein kinase 1 (S6K1) induced gene expression patterns similar to those seen in caloric restriction and led to increased lifespan and resistance to age-related pathologies, such as bone, immune, motor dysfunction and loss of insulin sensitivity in female mice. No significant lifespan effect was observed in males.
- % change in avg or median lifespan
- Median female lifespan is 19% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Deletion
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as rsks-1
- A homolog of this gene for Drosophila melanogaster is present as S6k
- A homolog of this gene for Saccharomyces cerevisiae is present as TPK3
- LongevityMap
- A homolog of this gene for Homo sapiens is present as RPS6KB1
- CellAge
- A homolog of this gene for Homo sapiens is present as RPS6KB1
- Caenorhabditis elegans
- rsks-1
- Danio rerio
- rps6kb1b
- Danio rerio
- rps6kb1a
- Drosophila melanogaster
- S6k
- Homo sapiens
- RPS6KB1
- Rattus norvegicus
- Rps6kb1
- Saccharomyces cerevisiae
- TPK3
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (72508)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Rps6kb1 (Mus musculus)