LongevityMap Gene
Gene details
- HGNC symbol
- RPS6KB1
- Aliases
- S6K; PS6K; S6K1; STK14A; p70-S6K; p70; S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha
- Common name
- ribosomal protein S6 kinase B1
- Description
- This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
- Cytogenetic Location
- 17q23.1
- UCSC Genome Browser
- View 17q23.1 on the UCSC genome browser
- OMIM
- 608938
- Ensembl
- ENSG00000108443
- UniProt/Swiss-Prot
- KS6B1_HUMAN
- Entrez Gene
- 6198
- UniGene
- 463642
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rsks-1
- Danio rerio
- rps6kb1a
- Danio rerio
- rps6kb1b
- Drosophila melanogaster
- S6k
- Mus musculus
- Rps6kb1
- Rattus norvegicus
- Rps6kb1
- Saccharomyces cerevisiae
- TPK3
In other databases
- GenAge model organism genes
- CellAge
- This gene is present as RPS6KB1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
- Conclusions
- As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
- Indentifier
- RPS6KB1
- Reference