- Symbol
- rsks-1
- Name
- RSK-pSeventy (RSK-p70 kinase) homolog
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Translational regulator
- Observations
- RNA interference reducing S6K (rsks-1) mRNA levels by about two-fold extended mean lifespan 13-47% and maximum lifespan by up to 60%. Deletion mutants also lived longer. A life-extending effect was also observed in daf-16 mutants and sir-2.1 mutants but not in daf-2 mutants. TOR RNA interference further extended lifespan.
- % change in max lifespan
- Maximum lifespan is up to 60% higher.
- % change in avg or median lifespan
- Average lifespan is 13-47% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- RNAi resulted in a 22% maximum lifespan increase. In the rsks-1 (ok1255) mutant background, inhibition of ifg-1 led to a further extension of 40% in maximum lifespan. However, inhibition of let-363 (worm homologue of TOR) by RNAi in rsks-1 mutant background led to a slight shortening of MLS. In the daf-2 (e1370) mutant background, inhibition of either ifg-1 or rsks-1 further extended lifespan by 70% and 24%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan by 27% and 14%, respectively, in a daf-16 (mu86 ) background. Inhibition of either ifg-1 or rsks-1 in the clk-1(e2519) mutant background led to a further lifespan extension by 19% and 13%, respectively. Inhibition of either ifg-1 or rsks-1 extended lifespan in the eat-2 background by 54% and 11%, respectively. In a sir-2.1 mutant background, ifg-1 inhibition extended lifespan by 93% and rsks-1 inhibition by 33%.
- % change in max lifespan
- Maximum lifespan is 22% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Rps6kb1
- A homolog of this gene for Drosophila melanogaster is present as S6k
- A homolog of this gene for Saccharomyces cerevisiae is present as TPK3
- LongevityMap
- A homolog of this gene for Homo sapiens is present as RPS6KB1
- CellAge
- A homolog of this gene for Homo sapiens is present as RPS6KB1
- Danio rerio
- rps6kb1a
- Danio rerio
- rps6kb1b
- Drosophila melanogaster
- S6k
- Homo sapiens
- RPS6KB1
- Homo sapiens
- RPS6KB2
- Mus musculus
- Rps6kb1
- Mus musculus
- Rps6kb2
- Rattus norvegicus
- Rps6kb1
- Rattus norvegicus
- Rps6kb2
- Saccharomyces cerevisiae
- TPK3
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (176554)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar