Caenorhabditis elegansGenAge entry for daf-16 (Caenorhabditis elegans)

Gene information (ID: 160)

Symbol
daf-16
Name
Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16)
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Forkhead family transcription factor

Potential relevance to longevity and/or ageing

Observations
The increased lifespan of daf-2 and daf-23 mutants is suppressed completely by a daf-16 mutation.
Lifespan Effect
Not Recorded
Genetic Manipulation
Mutations
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mutations in daf-16 suppress the life-extension caused by several mutations, including daf-2.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Mutation
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      70% decrease in median lifespan in daf-2 background and 45% decrease in lifespan in wild-type background.
      % change in avg or median lifespan
      Average lifespan is 45% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      RNA interference
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Drosophila melanogaster is present as foxo
        • A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as FOXO1
        • A homolog of this gene for Homo sapiens is present as FOXO3
        • A homolog of this gene for Homo sapiens is present as FOXO4
        GenDR gene manipulations
        • A homolog of this gene for Drosophila melanogaster is present as foxo
        • A homolog of this gene for Mus musculus is present as Foxo3
        • This gene is present as daf-16
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as FOXO1
        • A homolog of this gene for Homo sapiens is present as FOXO3
        • A homolog of this gene for Homo sapiens is present as FOXO4
        CellAge
        • A homolog of this gene for Homo sapiens is present as FOXO3

        Homologs in other organisms

        Danio rerio
        foxo4
        Danio rerio
        si:dkey-11f5.5
        Danio rerio
        si:ch211-206a7.2
        Danio rerio
        foxo1b
        Danio rerio
        foxo1a
        Danio rerio
        foxo3a
        Danio rerio
        foxo3b
        Drosophila melanogaster
        foxo
        Homo sapiens
        FOXO3
        Homo sapiens
        FOXO1
        Homo sapiens
        FOXO4
        Homo sapiens
        FOXO6
        Mus musculus
        Foxo6
        Mus musculus
        Foxo4
        Mus musculus
        Foxo3
        Mus musculus
        Foxo1
        Rattus norvegicus
        Foxo4
        Rattus norvegicus
        Foxo3
        Rattus norvegicus
        Foxo1
        Rattus norvegicus
        Foxo6
        Saccharomyces cerevisiae
        HCM1

        External links

        WormBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (172981)
        Homologues
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        UniProt
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        Internet
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