- Symbol
- foxo
- Aliases
- 3143; Afx; anon-WO0118547.374; cg3143; CG3143; dfoxo; dF
- Name
- Forkhead box, sub-group O
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- Transcriptional regulator
- Observations
- Overexpression extends lifespan.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- dFOXO, a downstream effector of the insulin/insulin-like growth factor signaling, was overexpressed in the adult Drosophila fat body, which increased lifespan and reduced fecundity of females but had no effect on male lifespan.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Age-specific mortality analysis showed that overexpression of dFOXO in the fat-body of adult females increased median (by 21-33%) and maximum lifespan and lowered the age-specific mortality compared to control flies at all ages, in two independent experiments. Initiation of dFOXO overexpression at different ages increased subsequent lifespan compared to controls, with the magnitude of the increase decreasing as the flies were put on RU486 at older age. The effects of removal of dFOXO overexpression at different ages closely mirrored those of induction of expression , and produced shorter lifespan compared to +RU486 controls, with the shortest lifespans observed in flies taken off RU486 at the earlier ages.
- % change in avg or median lifespan
- Median lifespan is 21-33% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as daf-16
- A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as FOXO1
- A homolog of this gene for Homo sapiens is present as FOXO3
- A homolog of this gene for Homo sapiens is present as FOXO4
- GenDR gene manipulations
- This gene is present as foxo
- A homolog of this gene for Mus musculus is present as Foxo3
- A homolog of this gene for Caenorhabditis elegans is present as daf-16
- LongevityMap
- A homolog of this gene for Homo sapiens is present as FOXO1
- A homolog of this gene for Homo sapiens is present as FOXO3
- A homolog of this gene for Homo sapiens is present as FOXO4
- CellAge
- A homolog of this gene for Homo sapiens is present as FOXO1
- A homolog of this gene for Homo sapiens is present as FOXO3
- A homolog of this gene for Homo sapiens is present as FOXO4
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo3a
- Danio rerio
- si:dkey-11f5.5
- Danio rerio
- foxo1b
- Danio rerio
- foxo1a
- Danio rerio
- foxo4
- Danio rerio
- si:ch211-206a7.2
- Danio rerio
- foxo3b
- Homo sapiens
- FOXO4
- Homo sapiens
- FOXO1
- Homo sapiens
- FOXO6
- Homo sapiens
- FOXO3
- Mus musculus
- Foxo3
- Mus musculus
- Foxo1
- Mus musculus
- Foxo6
- Mus musculus
- Foxo4
- Rattus norvegicus
- Foxo4
- Rattus norvegicus
- Foxo3
- Rattus norvegicus
- Foxo1
- Rattus norvegicus
- Foxo6
- Saccharomyces cerevisiae
- HCM1
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (41709)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for foxo (Drosophila melanogaster)