Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: foxo

Gene Information (Entrez Gene ID: 41709)

Symbol
foxo
Aliases
3143 Afx anon-WO0118547.374 cg3143 CG3143 dfoxo dFoxo dFoxO dFOXO Dfoxo Dmel\CG3143 DmQ95V5 fd88A FKHR foxO Foxo FoxO FOXO foxo|dFOXO Q95V55
Name
Forkhead box, sub-group O
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
41709

Potential relevance to dietary restriction and ageing

Observations

foxo overexpression extends lifespan. Activation of foxo in the adult pericerebral fat body is sufficient for lifespan extension. Limited activation of foxo reduces the expression of Drosophila insulin-like peptide dilp-2 synthesised in neurons and, represses endogenous insulin-dependent signalling in peripheral fat body [1091]. foxo is not required for DR, but its activity modulates the response. foxo null mutants are shorter-lived than wild-type on all food dilutions apart from 0.1 SY and under starvation. foxo overexpression in adult fat body under normal nutrition leads to extension of lifespan of females and causes an attenuated lifespan response to DR [2578].

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as daf-16
    • This gene is present as foxo
    • A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as FOXO1
    • A homolog of this gene for Homo sapiens is present as FOXO3
    • A homolog of this gene for Homo sapiens is present as FOXO4
    GenDR gene manipulations
    • A homolog of this gene for Mus musculus is present as Foxo3
    • A homolog of this gene for Caenorhabditis elegans is present as daf-16
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as FOXO1
    • A homolog of this gene for Homo sapiens is present as FOXO3
    • A homolog of this gene for Homo sapiens is present as FOXO4
    CellAge
    • A homolog of this gene for Homo sapiens is present as FOXO3

    Homologs

    Caenorhabditis elegans
    daf-16
    Danio rerio
    foxo3a
    Danio rerio
    si:dkey-11f5.5
    Danio rerio
    foxo1b
    Danio rerio
    foxo1a
    Danio rerio
    foxo4
    Danio rerio
    si:ch211-206a7.2
    Danio rerio
    foxo3b
    Homo sapiens
    FOXO4
    Homo sapiens
    FOXO1
    Homo sapiens
    FOXO6
    Homo sapiens
    FOXO3
    Mus musculus
    Foxo3
    Mus musculus
    Foxo1
    Mus musculus
    Foxo6
    Mus musculus
    Foxo4
    Rattus norvegicus
    Foxo4
    Rattus norvegicus
    Foxo3
    Rattus norvegicus
    Foxo1
    Rattus norvegicus
    Foxo6
    Saccharomyces cerevisiae
    HCM1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 41709
    Homologues
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    UniProt
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    Internet
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