Cell Senescence Entries for FOXO4

Cell Types
Osteosarcoma, Thyroid gland cancer
Cell Lines
A14, U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
de Keizer et al. (2010) Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res 70(21)8526-36 (PubMed)

FOXO4 Gene Information

HGNC symbol
FOXO4 
Aliases
AFX1; MLLT7 
Common name
forkhead box O4 
Entrez Id
4303
Description
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].

FOXO4 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:7517; muscle organ development
GO:6357; regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:48863; stem cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:16525; negative regulation of angiogenesis
GO:8286; insulin receptor signaling pathway
GO:51151; negative regulation of smooth muscle cell differentiation
And 8 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5829; cytosol
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
And 3 more GO terms
Show all GO terms

Homologs of FOXO4 in Model Organisms

Caenorhabditis elegans
daf-16
Danio rerio
foxo4
Drosophila melanogaster
foxo
Mus musculus
Foxo4
Rattus norvegicus
Foxo4
Saccharomyces cerevisiae
HCM1
Schizosaccharomyces pombe
sep1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-16
  • A homolog of this gene for Drosophila melanogaster is present as foxo
  • A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
GenAge human genes
  • This gene is present as FOXO4
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as foxo
  • A homolog of this gene for Caenorhabditis elegans is present as daf-16
LongevityMap
  • This gene is present as FOXO4

External links

OMIM
300033
Ensembl
ENSG00000184481
Entrez Gene
4303
UniGene
584654
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXO4
GeneCards
FOXO4