LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- German
- Study Design
- 16 known FOXO3A SNPs were examined in 1,762 German centenarians/nonagenarians and younger controls
- Conclusions
- Polymorphisms in FOXO3A were associated with longevity. The FOXO3A association was considerably stronger in centenarians than in nonagenarians, highlighting the importance of centenarians for genetic longevity research. Replication in 535 French centenarians (mean age: 103.8 years) and 553 younger controls (aged 18–70 years) generated a trend that supported the results, although it was not statistically significant.
Variants (16)
- Gene summary:
- No gene (7)
- AFG1L (1)
- FOXO3 (8)
No gene
AFG1L
Gene details
- HGNC symbol
- AFG1L
- Aliases
- AFG1; LACE1; c222389
- Common name
- AFG1 like ATPase
- Description
- This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
- OMIM
- Ensembl
- ENSG00000135537
- UniProt/Swiss-Prot
- LACE1_HUMAN
- Entrez Gene
- 246269
- UniGene
- 259666
- HapMap
- View on HapMap
Homologs in model organisms
FOXO3
Gene details
- HGNC symbol
- FOXO3
- Aliases
- FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
- Common name
- forkhead box O3
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 101
- OMIM
- 602681
- Ensembl
- ENSG00000118689
- UniProt/Swiss-Prot
- FOXO3_HUMAN
- Entrez Gene
- 2309
- UniGene
- 220950
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo3a
- Danio rerio
- foxo3b
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo3
- Rattus norvegicus
- Foxo3
- Saccharomyces cerevisiae
- HCM1