A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling.
16 known FOXO3A SNPs were examined in 1,762 German centenarians/nonagenarians and younger controls
Conclusions
Polymorphisms in FOXO3A were associated with longevity. The FOXO3A association was considerably stronger in centenarians than in nonagenarians, highlighting the importance of centenarians for genetic longevity research. Replication in 535 French centenarians (mean age: 103.8 years) and 553 younger controls (aged 18–70 years) generated a trend that supported the results, although it was not statistically significant.
This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
