GenAge entry for SLC13A1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 270)

HGNC symbol
SLC13A1 
Aliases
NaSi-1; NAS1 
Common name
solute carrier family 13 (sodium/sulfate symporter), member 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

SLC13A1, also known as NaS1, is one of the members of the solute carrier family (sodium/sulfate symporters) and has a role in mediating sulfate reabsorption in the kidney. It appears to be involved in kidney disease.

Knockout NaS1 mice (Nas1 -/- ) were found to live longer and have less tumors in aged mice. Median lifespans was increased in both male and female mice when compared with wild type [2172]. Similar results were observed for orthologs of SLC13A1 in flies [2173] and worm [2174]. Therefore, results from model systems support a role for SLC13A1 in ageing, although further studies are necessary to determine if it also plays a role in human ageing.

Cytogenetic information

Cytogenetic band
7q31.32
Location
123,113,534 bp to 123,199,971 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0008272; sulfate transport
GO:0035725; sodium ion transmembrane transport
GO:1902358; sulfate transmembrane transport
Cellular component: GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
Function: GO:0015382; sodium:sulfate symporter activity
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for SLC13A1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
nac-1
Caenorhabditis elegans
nac-3
Danio rerio
slc13a1
Drosophila melanogaster
CG33934
Drosophila melanogaster
Indy-2
Drosophila melanogaster
Indy
Drosophila melanogaster
CG7309
Mus musculus
Slc13a1
Rattus norvegicus
Slc13a1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Indy
  • A homolog of this gene for Caenorhabditis elegans is present as nac-3
  • A homolog of this gene for Mus musculus is present as Slc13a1
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as Indy

Selected references

External links

EPD
ORF Accession
NM_022444
CDS Accession
NP_071889
OMIM
606193
HPRD
08394
Ensembl
SLC13A1
UniProt/Swiss-Prot
A4D0X1_HUMAN
GeneCards
SLC13A1
Entrez Gene
6561
GenAtlas
SLC13A1
Internet
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