GenAge entry for DGAT1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 291)

HGNC symbol
DGAT1 
Aliases
ARGP1; DGAT 
Common name
diacylglycerol O-acyltransferase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

DGAT1 is an enzyme involved in triglyceride synthesis and metabolism. Knockout of DGAT1 in female mice results in an extended lifespan of about 23% [3249]. As such, DGAT1 might play some role in ageing, though human studies are lacking.

Cytogenetic information

Cytogenetic band
8q24.3
Location
144,314,583 bp to 144,326,919 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006641; triglyceride metabolic process
GO:0019432; triglyceride biosynthetic process
GO:0019915; lipid storage
GO:0034379; very-low-density lipoprotein particle assembly
GO:0035336; long-chain fatty-acyl-CoA metabolic process
GO:0036155; acylglycerol acyl-chain remodeling
GO:0042572; retinol metabolic process
GO:0046339; diacylglycerol metabolic process
GO:0055089; fatty acid homeostasis
Cellular component: GO:0005789; endoplasmic reticulum membrane
GO:0016021; integral component of membrane
Function: GO:0003846; 2-acylglycerol O-acyltransferase activity
GO:0004144; diacylglycerol O-acyltransferase activity
GO:0005515; protein binding
GO:0016746; transferase activity, transferring acyl groups
GO:0050252; retinol O-fatty-acyltransferase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
DGAT1
STRING interaction network
Protein-Protein network diagram for DGAT1

Retrieve sequences for DGAT1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
mboa-2
Danio rerio
dgat1a
Danio rerio
dgat1b
Drosophila melanogaster
mdy
Mus musculus
Dgat1
Rattus norvegicus
Dgat1
Saccharomyces cerevisiae
ARE1
Saccharomyces cerevisiae
ARE2
Schizosaccharomyces pombe
are1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Dgat1

Selected references

External links

EPD
ORF Accession
NM_012079
CDS Accession
NP_036211
OMIM
604900
HPRD
05360
Ensembl
DGAT1
UniProt/Swiss-Prot
DGAT1_HUMAN
GeneCards
DGAT1
Entrez Gene
8694
GenAtlas
DGAT1
Internet
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