LongevityMap variant

Entry Details

Longevity Association: Significant
Population: French
Study Design: Common polymorphism (E2, E3, and E4) was examined in 560 centenarians and 560 adult controls
Conclusions: Significant differences were observed between centenarians and controls for allelic and genotypic frequencies. The E4E4 genotype was under-represented in centenarians compared to controls. Centenarians carrying at least one E2 allele or homozygous for E3 were more frequent than controls.

Identifier: E2/E3/E4
In Other Studies (IDs): 5 8 9 11 14 51 68 86 99 131 171 190 224 229 373 374 3476
Cytogenetic Location: 19q13.32
UCSC Genome Browser: View 19q13.32 on the UCSC genome browser

HGNC symbol: APOE
Aliases: AD2; LPG; APO-E; ApoE4; LDLCQ5
Common name: apolipoprotein E
Description: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
Other longevity studies of this gene: 30
OMIM: 107741
Ensembl: ENSG00000130203
UniProt/Swiss-Prot: A0A0S2Z3D5_HUMAN
Entrez Gene: 348
UniGene: 654439
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

GenAge microarray genes

Blanché et al. (2001)