LongevityMap variant
- Longevity Association
- Significant
- Population
- Chinese (Han)
- Study Design
- the relationship between APOE and longevity was analyzed among 1562 Han Chinese (ages ranged from 20-108 years, 246 female and 1316 male)
- Conclusions
- The allele frequency of APOE*4 in the very old age group (> or = 85 years) was significantly different from that in the youth (20-39 years), middle (40-59 years) and old (60-84 years) age group (2.5% vs 8.4, 7.9 or 7.6%; P < 0.05), respectively
- HGNC symbol
- APOE
- Aliases
- AD2; LPG; APO-E; ApoE4; LDLCQ5
- Common name
- apolipoprotein E
- Description
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
- Other longevity studies of this gene
- 30
- OMIM
- 107741
- Ensembl
- ENSG00000130203
- UniProt/Swiss-Prot
- A0A0S2Z3D5_HUMAN
- Entrez Gene
- 348
- UniGene
- 654439
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- apoea
- Danio rerio
- apoeb
- Mus musculus
- Apoe
- Rattus norvegicus
- Apoe
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Apoe
- GenAge human genes
- This gene is present as APOE
- GenAge microarray genes
- This gene is present as APOE
Jian-Gang et al. (1998)
Other variants which are also part of this study
