LongevityMap variant
- Longevity Association
- Significant
- Population
- Greek
- Study Design
- The prevalence of genotypes in 80 healthy aged individuals (>80 years) and 391 adults (median age 43 years) was examined
- Conclusions
- Genotypes were comparable in both groups with the exception of E3/3 and E3/4, which were significantly higher and lower, respectively, in aged individuals. The epsilon2 and epsilon3 allele frequencies were not different between the groups. The epsilon4 allele was significantly less frequent in aged individuals compared to controls.
- HGNC symbol
- APOE
- Aliases
- AD2; LPG; APO-E; ApoE4; LDLCQ5
- Common name
- apolipoprotein E
- Description
- The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
- Other longevity studies of this gene
- 30
- OMIM
- 107741
- Ensembl
- ENSG00000130203
- UniProt/Swiss-Prot
- A0A0S2Z3D5_HUMAN
- Entrez Gene
- 348
- UniGene
- 654439
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- apoea
- Danio rerio
- apoeb
- Mus musculus
- Apoe
- Rattus norvegicus
- Apoe
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Apoe
- GenAge human genes
- This gene is present as APOE
- GenAge microarray genes
- This gene is present as APOE
Stakias et al. (2006)
Other variants which are also part of this study
