LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Danish
- Study Design
- 15 SNPs that covered FOXO3A common variation were examined in 1089 oldest old and 736 middle-aged for longevity association by longitudinal study design as well as case-control study design
- Conclusions
- 4 SNPs previously reported to be associated with longevity were verified in this study. 4 novel SNPs (rs12206094, rs13220810, rs7762395, and rs9486902 (corrected P-values 0.001–0.044)) and two haplotypes(corrected P-values: 0.01–0.03) associated with longevity were found in this study. FOXO3A was a candidate longevity gene for survival from younger ages to old age, yet not during old age.
- Identifier
- rs13217795
- In Other Studies (IDs)
- 470 570
- Cytogenetic Location
- 6q21
- UCSC Genome Browser
- View 6q21 on the UCSC genome browser
Gene details
- HGNC symbol
- FOXO3
- Aliases
- FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
- Common name
- forkhead box O3
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 101
- OMIM
- 602681
- Ensembl
- ENSG00000118689
- UniProt/Swiss-Prot
- FOXO3_HUMAN
- Entrez Gene
- 2309
- UniGene
- 220950
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo3a
- Danio rerio
- foxo3b
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo3
- Rattus norvegicus
- Foxo3
- Saccharomyces cerevisiae
- HCM1

