LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Germany, Italian, Chinese (Han)
Study Design: 36 haplotype-tagging SNPs (htSNPs) in the gene regions of FOXO1, FOXO4, and FOXO6 were examined in Germany cohort which consist of 1447 centenarians/nonagenarians (95-110 y, mean age: 98.8 y, approx. 75% female) and 1029 younger controls (60-75 y, mean age: 66.8 y, approx. 75% female) for longevity association analysis. Then these htSNPs were examined in Italian women samples which consist of 166 long-lived individuals (90–109 years, mean age: 98.39 years) and 216 younger controls (18–48 years; mean age: 31.06 years).
Conclusions: None of the FOXO1, FOXO4, and FOXO6 genes plays a significant role in the ability to reach old age in Germany. FOXO1 was not associated with longevity in Italian either.

HGNC symbol: FOXO1
Aliases: FKH1; FKHR; FOXO1A
Common name: forkhead box O1
Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 30
OMIM: 136533
Ensembl: ENSG00000150907
UniProt/Swiss-Prot: FOXO1_HUMAN
Entrez Gene: 2308
UniGene: 370666
HapMap: View on HapMap

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Kleindorp et al. (2011)