LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Germany, Italian, Chinese (Han)
- Study Design
- 36 haplotype-tagging SNPs (htSNPs) in the gene regions of FOXO1, FOXO4, and FOXO6 were examined in Germany cohort which consist of 1447 centenarians/nonagenarians (95-110 y, mean age: 98.8 y, approx. 75% female) and 1029 younger controls (60-75 y, mean age: 66.8 y, approx. 75% female) for longevity association analysis. Then these htSNPs were examined in Italian women samples which consist of 166 long-lived individuals (90–109 years, mean age: 98.39 years) and 216 younger controls (18–48 years; mean age: 31.06 years).
- Conclusions
- None of the FOXO1, FOXO4, and FOXO6 genes plays a significant role in the ability to reach old age in Germany. FOXO1 was not associated with longevity in Italian either.
- HGNC symbol
- FOXO1
- Aliases
- FKH1; FKHR; FOXO1A
- Common name
- forkhead box O1
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 30
- OMIM
- 136533
- Ensembl
- ENSG00000150907
- UniProt/Swiss-Prot
- FOXO1_HUMAN
- Entrez Gene
- 2308
- UniGene
- 370666
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo1a
- Danio rerio
- foxo1b
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo1
- Rattus norvegicus
- Foxo1
- Saccharomyces cerevisiae
- HCM1
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as daf-16
- A homolog of this gene for Drosophila melanogaster is present as foxo
- A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
- GenAge human genes
- This gene is present as FOXO1
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as foxo
- A homolog of this gene for Caenorhabditis elegans is present as daf-16
- CellAge
- This gene is present as FOXO1
Kleindorp et al. (2011)
Other variants which are also part of this study