GenAge entry for APEX1 (Homo sapiens)
Gene name (HAGRID: 195)
- HGNC symbol
- APEX1
- Aliases
- APE; REF1; HAP1; APX; APEN; REF-1; APE-1; APEX
- Common name
- APEX nuclease (multifunctional DNA repair enzyme) 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
APEX1 repairs oxidative DNA damage. Disruption of APEX1 in mice results in embryonic lethality [854]. Heterozygous mice had an elevated spontaneous mutation frequency [1732]. Whether APEX1 is involved in human ageing remains to be established.
Cytogenetic information
- Cytogenetic band
- 14q11.2
- Location
- 20,455,131 bp to 20,457,772 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000723; telomere maintenance
GO:0006281; DNA repair
GO:0006284; base-excision repair
GO:0006286; base-excision repair, base-free sugar-phosphate removal
GO:0006310; DNA recombination
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0007568; aging
GO:0014912; negative regulation of smooth muscle cell migration
GO:0042493; response to drug
GO:0043488; regulation of mRNA stability
And 11 more GO terms Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005813; centrosome
GO:0005840; ribosome
GO:0016607; nuclear speck
And 2 more GO terms Function: GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0003713; transcription coactivator activity
GO:0003714; transcription corepressor activity
GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004519; endonuclease activity
GO:0004520; endodeoxyribonuclease activity
GO:0004523; RNA-DNA hybrid ribonuclease activity
GO:0004528; phosphodiesterase I activity
GO:0004844; uracil DNA N-glycosylase activity
And 13 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, TXN, STAT3, HDAC3, HIF1A, RPA1, UBE2I, EP300, TERF1, XRCC5, PCNA, FEN1, TERF2, APP, SIRT1, HDAC1, HDAC2, MDM2, POLB, BUB3
- STRING interaction network
Retrieve sequences for APEX1
Homologs in model organisms
- Caenorhabditis elegans
- exo-3
- Danio rerio
- apex1
- Drosophila melanogaster
- Rrp1
- Mus musculus
- Apex1
- Rattus norvegicus
- Apex1
- Saccharomyces cerevisiae
- APN2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as exo-3
- LongevityMap
- This gene is present as APEX1
- CellAge
- This gene is present as APEX1
- CellAge gene expression
- This gene is present as APEX1