Cell Senescence Entries for APEX1
- Cell Types
- Foreskin fibroblast, Skin fibroblast
- Cell Lines
- BJ, BJ-5ta, GM00969, GM05565
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Li et al. (2019) APE1 deficiency promotes cellular senescence and premature aging features. Nucleic Acids Res 46(11)5664-5677 (PubMed)
APEX1 Gene Information
- HGNC symbol
- APEX1
- Aliases
- APE; APE-1; APEN; APEX; APX; HAP1; REF-1; REF1
- Common name
- apurinic/apyrimidinic endodeoxyribonuclease 1
- Entrez Id
- 328
- Description
- The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019].
APEX1 Ontologies
- Gene Ontology
-
Process: GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:45892; negative regulation of transcription, DNA-templated
GO:6310; DNA recombination
GO:43488; regulation of mRNA stability
GO:80111; DNA demethylation
GO:42981; regulation of apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6284; base-excision repair
And 15 more GO terms Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5840; ribosome
GO:5813; centrosome
GO:5730; nucleolus
GO:48471; perinuclear region of cytoplasm
And 2 more GO terms Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:31490; chromatin DNA binding
GO:4518; nuclease activity
GO:5515; protein binding
GO:4519; endonuclease activity
GO:4527; exonuclease activity
And 22 more GO terms
Homologs of APEX1 in Model Organisms
- Caenorhabditis elegans
- exo-3
- Danio rerio
- apex1
- Drosophila melanogaster
- Rrp1
- Mus musculus
- Apex1
- Rattus norvegicus
- Apex1
- Saccharomyces cerevisiae
- APN2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as exo-3
- GenAge human genes
- This gene is present as APEX1
- LongevityMap
- This gene is present as APEX1
- CellAge gene expression
- This gene is present as APEX1
External links
- OMIM
- 107748
- Ensembl
- ENSG00000100823
- Entrez Gene
- 328
- UniGene
- 73722
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- APEX1
- GeneCards
- APEX1