Cell Senescence Entries for HMGB2
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown, Knockout
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Aird et al. (2017) HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci. J Cell Biol 215(3)325-334 (PubMed)
HMGB2 Gene Information
- HGNC symbol
- HMGB2
- Aliases
- HMG2
- Common name
- high mobility group box 2
- Entrez Id
- 3148
- Description
- This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008].
HMGB2 Ontologies
- Gene Ontology
-
Process: GO:6325; chromatin organization
GO:6334; nucleosome assembly
GO:6935; chemotaxis
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6310; DNA recombination
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:45087; innate immune response
GO:6954; inflammatory response
GO:6357; regulation of transcription by RNA polymerase II
And 29 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5576; extracellular region
GO:5694; chromosome
GO:5615; extracellular space
GO:48471; perinuclear region of cytoplasm
GO:793; condensed chromosome
GO:785; chromatin
And 1 more GO terms Function: GO:5515; protein binding
GO:3723; RNA binding
GO:3677; DNA binding
GO:8134; transcription factor binding
GO:3684; damaged DNA binding
GO:3713; transcription coactivator activity
GO:400; four-way junction DNA binding
GO:97100; supercoiled DNA binding
GO:976; transcription cis-regulatory region binding
GO:3690; double-stranded DNA binding
GO:8301; DNA binding, bending
And 8 more GO terms
Homologs of HMGB2 in Model Organisms
- Caenorhabditis elegans
- hmg-1.2
- Danio rerio
- hmgb2a
- Drosophila melanogaster
- Dsp1
- Mus musculus
- Hmgb2
- Rattus norvegicus
- RGD1559962
- Rattus norvegicus
- Hmgb2l1
- Rattus norvegicus
- RGD1561694
- Rattus norvegicus
- Hmgb2
- Rattus norvegicus
- Hmgb2l1
- Saccharomyces cerevisiae
- NHP6A
- Saccharomyces cerevisiae
- NHP6B
In other databases
External links
- OMIM
- 163906
- Ensembl
- ENSG00000164104
- Entrez Gene
- 3148
- UniGene
- 434953
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HMGB2
- GeneCards
- HMGB2