GenAge entry for TRPV1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 306)

HGNC symbol: TRPV1
Aliases: VR1
Common name: transient receptor potential cation channel subfamily V member 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: The transient receptor potential cation channel subfamily V member 1 (TRPV1) is expressed in sensory neurons and is responsible for detecting extremely high temperatures and painful stimuli. Mutant mice lacking TRPV1 are long-lived (both in terms of median and maximum lifespan) and display a young metabolic profile at old age. Median lifespan is extended in both genders, with 11.9% increase in males and 15.9% for females. Mutant mice display a reduced cancer incidence, improved cognitive functions and spatial memory, and a delayed decline in motor coordination. Mutants do not have reduced growth rate or altered insulin levels, but are more glucose tolerant [3532].

Cytogenetic information

Cytogenetic band: 17p13.2
Location: 3,565,445 bp to 3,609,410 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001660; fever generation
GO:0001774; microglial cell activation
GO:0002024; diet induced thermogenesis
GO:0002790; peptide secretion
GO:0006629; lipid metabolic process
GO:0006810; transport
GO:0007166; cell surface receptor signaling pathway
GO:0007635; chemosensory behavior
GO:0014047; glutamate secretion
GO:0034605; cellular response to heat
GO:0043065; positive regulation of apoptotic process
GO:0043434; response to peptide hormone
GO:0045429; positive regulation of nitric oxide biosynthetic process
GO:0048266; behavioral response to pain
GO:0050954; sensory perception of mechanical stimulus
GO:0050955; thermoception
GO:0050960; detection of temperature stimulus involved in thermoception
GO:0050965; detection of temperature stimulus involved in sensory perception of pain
GO:0050968; detection of chemical stimulus involved in sensory perception of pain
GO:0051209; release of sequestered calcium ion into cytosol
GO:0051289; protein homotetramerization
GO:0060083; smooth muscle contraction involved in micturition
GO:0060454; positive regulation of gastric acid secretion
GO:0070588; calcium ion transmembrane transport
GO:0071312; cellular response to alkaloid
GO:0071318; cellular response to ATP
GO:0071356; cellular response to tumor necrosis factor
GO:0071468; cellular response to acidic pH
GO:0071502; cellular response to temperature stimulus
GO:0090212; negative regulation of establishment of blood-brain barrier
GO:1901594; response to capsazepine
GO:1990035; calcium ion import into cell
GO:1990090; cellular response to nerve growth factor stimulus

Cellular component:

GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0016021; integral component of membrane
GO:0030054; cell junction
GO:0030425; dendrite
GO:0031226; intrinsic component of plasma membrane
GO:0032591; dendritic spine membrane
GO:0043025; neuronal cell body
GO:0045211; postsynaptic membrane

Function:

GO:0004888; transmembrane signaling receptor activity
GO:0005230; extracellular ligand-gated ion channel activity
GO:0005231; excitatory extracellular ligand-gated ion channel activity
GO:0005262; calcium channel activity
GO:0005516; calmodulin binding
GO:0005524; ATP binding
GO:0015278; calcium-release channel activity
GO:0017081; chloride channel regulator activity
GO:0035091; phosphatidylinositol binding
GO:0042802; identical protein binding
GO:0046872; metal ion binding
GO:0051219; phosphoprotein binding
GO:0097603; temperature-gated ion channel activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, TRPV1
STRING interaction network

Retrieve sequences for TRPV1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: ocr-2
Caenorhabditis elegans: ocr-3
Caenorhabditis elegans: ocr-1
Caenorhabditis elegans: ocr-4
Caenorhabditis elegans: osm-9
Danio rerio: trpv1
Drosophila melanogaster: nan
Drosophila melanogaster: iav
Mus musculus: Trpv1
Rattus norvegicus: Trpv1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as ocr-2
A homolog of this gene for Mus musculus is present as Trpv1