Drosophila melanogasterGenAge entry for Atg8a (Drosophila melanogaster)

Gene information (ID: 22)

Symbol
Atg8a
Aliases
atg8; Atg8; Atg8/LC3; atg8a; Atg8A; ATG8a; BcDNA:LD05816
Name
Autophagy-related 8a
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Involved in autophagy

Potential relevance to longevity and/or ageing

Observations
15% maximum lifespan reduction at 25 C, 20% maximum lifespan reduction at 29 C.
% change in max lifespan
Maximum lifespan is up to 20% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference
    Observations
    Mutations resulted in reduced lifespan and increased sensitivity to oxidative stress while enhanced expression in older fly brains extended average adult lifespan by 56% and promoted resistance to oxidative stress.
    % change in avg or median lifespan
    Average lifespan is 56% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Increases the resistance to oxidative stress and extends the average lifespan up to 56%.
      % change in avg or median lifespan
      Average lifespan is up to 56% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Overexpression
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Caenorhabditis elegans is present as lgg-1
        • A homolog of this gene for Saccharomyces cerevisiae is present as ATG8
        GenDR gene manipulations
        • A homolog of this gene for Saccharomyces cerevisiae is present as ATG8
        CellAge gene expression
        • A homolog of this gene for Homo sapiens is present as GABARAP

        Homologs in other organisms

        Caenorhabditis elegans
        lgg-1
        Danio rerio
        gabarapa
        Danio rerio
        gabarapb
        Homo sapiens
        GABARAP
        Mus musculus
        Gabarap
        Rattus norvegicus
        Gabarap
        Saccharomyces cerevisiae
        ATG8

        External links

        FlyBase
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        Ensembl
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        Entrez Gene
        View on Entrez Gene database (32001)
        Homologues
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        UniProt
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        Internet
        Search Google or Search Google Scholar