- Symbol
- Atg8a
- Aliases
- atg8; Atg8; Atg8/LC3; atg8a; Atg8A; ATG8a; BcDNA:LD05816
- Name
- Autophagy-related 8a
- Organism
- Drosophila melanogaster (AnAge)
- Known functions and activities
- Involved in autophagy
- Observations
- 15% maximum lifespan reduction at 25 C, 20% maximum lifespan reduction at 29 C.
- % change in max lifespan
- Maximum lifespan is up to 20% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Mutations resulted in reduced lifespan and increased sensitivity to oxidative stress while enhanced expression in older fly brains extended average adult lifespan by 56% and promoted resistance to oxidative stress.
- % change in avg or median lifespan
- Average lifespan is 56% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Increases the resistance to oxidative stress and extends the average lifespan up to 56%.
- % change in avg or median lifespan
- Average lifespan is up to 56% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as lgg-1
- A homolog of this gene for Saccharomyces cerevisiae is present as ATG8
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as ATG8
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as GABARAP
- Caenorhabditis elegans
- lgg-1
- Danio rerio
- gabarapa
- Danio rerio
- gabarapb
- Homo sapiens
- GABARAP
- Mus musculus
- Gabarap
- Rattus norvegicus
- Gabarap
- Saccharomyces cerevisiae
- ATG8
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (32001)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Atg8a (Drosophila melanogaster)