Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: ATG8

Gene Information (Entrez Gene ID: 852200)

Symbol
ATG8
Aliases
APG8 AUT7 CVT5
Name
ubiquitin-like protein ATG8
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
852200

Potential relevance to dietary restriction and ageing

Observations

Methionine restriction (a form of dietary restriction), aquired through MET2 or MET17 knockout, enhances lifespan in yeast. In both MET2 and MET17 models, this lifespan extension is abolished by the deletion of ATG5, ATG7, or ATG8 lifespan reaching comparable or even lower survival levels to those of controls.

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as Atg8a
    • A homolog of this gene for Caenorhabditis elegans is present as lgg-1
    • This gene is present as ATG8
    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as GABARAP
    • A homolog of this gene for Homo sapiens is present as GABARAPL1
    • A homolog of this gene for Homo sapiens is present as MAP1LC3B

    Homologs

    Caenorhabditis elegans
    lgg-1
    Caenorhabditis elegans
    lgg-2
    Danio rerio
    gabarapa
    Danio rerio
    map1lc3b
    Danio rerio
    map1lc3c
    Danio rerio
    gabarapl2
    Danio rerio
    GABARAPL1
    Danio rerio
    gabarapb
    Danio rerio
    map1lc3a
    Danio rerio
    map1lc3cl
    Drosophila melanogaster
    Atg8b
    Drosophila melanogaster
    Atg8a
    Homo sapiens
    MAP1LC3B
    Homo sapiens
    MAP1LC3C
    Homo sapiens
    MAP1LC3B2
    Homo sapiens
    MAP1LC3A
    Homo sapiens
    GABARAPL1
    Homo sapiens
    GABARAP
    Homo sapiens
    GABARAPL2
    Mus musculus
    Gabarap
    Mus musculus
    Map1lc3a
    Mus musculus
    Gabarapl2
    Mus musculus
    Map1lc3b
    Mus musculus
    Gabarapl1
    Rattus norvegicus
    AABR07072668.1
    Rattus norvegicus
    Map1lc3b2
    Rattus norvegicus
    AABR07048308.1
    Rattus norvegicus
    Map1lc3b
    Rattus norvegicus
    Map1lc3a
    Rattus norvegicus
    Gabarapl2
    Rattus norvegicus
    Gabarapl1
    Rattus norvegicus
    Gabarapl2
    Rattus norvegicus
    Gabarap
    Schizosaccharomyces pombe
    atg8

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 852200
    Homologues
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    UniProt
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    Internet
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