Cell Senescence Entries for MAPK12

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    MAPK12 Gene Information

    HGNC symbol
    MAPK12 
    Aliases
    ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK; 12; P38GAMMA 
    Common name
    mitogen-activated protein kinase 12 
    Entrez Id
    6300
    Description
    Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]

    MAPK12 Ontologies

    Gene Ontology
    Process: GO:6975; DNA damage induced protein phosphorylation
    GO:165; MAPK cascade
    GO:7050; cell cycle arrest
    GO:35556; intracellular signal transduction
    GO:7517; muscle organ development
    GO:45445; myoblast differentiation
    GO:18105; peptidyl-serine phosphorylation
    GO:51149; positive regulation of muscle cell differentiation
    GO:10952; positive regulation of peptidase activity
    GO:10468; regulation of gene expression
    GO:6355; regulation of transcription, DNA-templated
    And 4 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5739; mitochondrion
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:4707; MAP kinase activity
    GO:287; magnesium ion binding
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of MAPK12 in Model Organisms

    Caenorhabditis elegans
    pmk-2
    Caenorhabditis elegans
    pmk-1
    Danio rerio
    mapk12a
    Danio rerio
    mapk12b
    Drosophila melanogaster
    p38a
    Drosophila melanogaster
    p38b
    Drosophila melanogaster
    p38c
    Mus musculus
    Mapk12
    Rattus norvegicus
    Mapk12
    Saccharomyces cerevisiae
    HOG1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as p38b
    • A homolog of this gene for Drosophila melanogaster is present as Mpk2

    External links

    OMIM
    602399
    Ensembl
    ENSG00000188130
    Entrez Gene
    6300
    UniGene
    432642
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAPK12
    GeneCards
    MAPK12