DrugAge entry for Valproic acid

Name
Valproic acid 
Synonyms
2-Propylpentanoic acid • 2-Propylvaleric acid • 4-Heptanecarboxylic acid • 99-66-1 • Acide valproique • Acido valproico • Acidum valproicum • Convulex • Depakene • Depakin • Depakine • Di-n-propylacetic acid • Di-n-propylessigsaure • Dipropylacetate • Dipropylacetic acid • Ergenyl • Mylproin • Myproic Acid • n-Dipropylacetic acid • n-DPA • Pentanoic acid, 2-propyl- • Propylvaleric acid • Valproate • VALPROIC ACID • Vupral 
CAS Number
99-66-1 
IUPAC Name
2-propylpentanoic acid 
PubChem CID
3121 
SEP-L1000 side effects
Abdominal pain, Abdominal pain upper, Abnormal dreams, Abscess, Adenoma benign, Agitation, Agranulocytosis, Alanine aminotransferase increased, Alopecia, Amblyopia, Amenorrhoea, Amnesia, Amylase increased, Anaemia, Anaphylactic shock, Anxiety, Aplastic anaemia, Arrhythmia, Arthralgia, Arthropathy, Aspartate aminotransferase increased, Asthenia, Ataxia, Atrioventricular block, Atrophy, Back pain, Bleeding time prolonged, Body temperature decreased, Body temperature increased, Bone pain, Bradycardia, Breast enlargement, Breast feeding, Bronchitis, Catatonia, Chest pain, Chills, Coma, Confusional state, Congenital anomaly, Conjunctivitis, Constipation, Coordination abnormal, Cough, Cutaneous vasculitis, Cyst, Cystitis, Deafness, Death, Decreased appetite, Dementia, Depressed level of consciousness, Dermatitis bullous, Diarrhoea, Diplopia, Dizziness, Drug interaction, Drug withdrawal syndrome, Dry eye, Dry mouth, Dry skin, Dysarthria, Dysgeusia, Dyskinesia, Dysmenorrhoea, Dyspepsia, Dysphagia, Dyspnoea, Dysuria,  

Summary

Species No. Entries MAX(Avg Lifespan Change %) MAX(Max Lifespan Change %)

Results

Compound/Formulation Species Avg/Med Lifespan Change (%) Max Lifespan Change (%) Strain Dosage Significant? Reference

Lifespan Charts for Valproic acid


References

Evason, K et al. (2008) Valproic acid extends Caenorhabditis elegans lifespan. Aging Cell 7(3)305-317 PubMed
Janssens, GE et al. (2019) Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep 27(2)467-480.e6 PubMed

DGIdb Human Drug-Gene Interactions for Valproic acid

Interaction Types Gene Symbol Common Name Entrez Id DGIdb Sources Homologs References

Stitch DB Human Drug-Protein Interactions for Valproic acid

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id