A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling.
Abdominal pain, Abdominal pain upper, Abnormal dreams, Abscess, Adenoma benign, Agitation, Agranulocytosis, Alanine aminotransferase increased, Alopecia, Amblyopia, Amenorrhoea, Amnesia, Amylase increased, Anaemia, Anaphylactic shock, Anxiety, Aplastic anaemia, Arrhythmia, Arthralgia, Arthropathy, Aspartate aminotransferase increased, Asthenia, Ataxia, Atrioventricular block, Atrophy, Back pain, Bleeding time prolonged, Body temperature decreased, Body temperature increased, Bone pain, Bradycardia, Breast enlargement, Breast feeding, Bronchitis, Catatonia, Chest pain, Chills, Coma, Confusional state, Congenital anomaly, Conjunctivitis, Constipation, Coordination abnormal, Cough, Cutaneous vasculitis, Cyst, Cystitis, Deafness, Death, Decreased appetite, Dementia, Depressed level of consciousness, Dermatitis bullous, Diarrhoea, Diplopia, Dizziness, Drug interaction, Drug withdrawal syndrome, Dry eye, Dry mouth, Dry skin, Dysarthria, Dysgeusia, Dyskinesia, Dysmenorrhoea, Dyspepsia, Dysphagia, Dyspnoea, Dysuria,
Summary
Species
No. Entries
MAX(Avg Lifespan Change %)
MAX(Max Lifespan Change %)
Results
Compound/Formulation
Species
Avg/Med Lifespan Change (%)
Max Lifespan Change (%)
Strain
Dosage
Significant?
Reference
Lifespan Charts for Valproic acid
Average Lifespan
Max Lifespan
Hide Charts
References
Evason, K et al. (2008) Valproic acid extends Caenorhabditis elegans lifespan. Aging Cell 7(3)305-317 PubMed Janssens, GE et al. (2019) Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging. Cell Rep 27(2)467-480.e6 PubMed
DGIdb Human Drug-Gene Interactions for Valproic acid
Interaction Types
Gene Symbol
Common Name
Entrez Id
DGIdb Sources
Homologs
References
Stitch DB Human Drug-Protein Interactions for Valproic acid
Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.