Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: RPD3

Gene Information (Entrez Gene ID: 855386)

Symbol
RPD3
Aliases
MOF6 REC3 SDI2 SDS6
Name
Reduced Potassium Dependency 3
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
855386

Potential relevance to dietary restriction and ageing

Observations

Deletion of the histone deacetylase gene RPD3 extends lifespan by 41%, independently of an intact Sir silencing complex (in the short-lived YSK661 strain) [203]. Deletion of RPD3 extends replicative lifespan and there was no additive effect by neither 0.1% glucose nor amino acid restriction [2552].

References

    In other databases

    GenAge model organism genes
    • This gene is present as RPD3
    • A homolog of this gene for Drosophila melanogaster is present as Rpd3
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as HDAC1
    • A homolog of this gene for Homo sapiens is present as HDAC2
    • A homolog of this gene for Homo sapiens is present as HDAC3
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as Rpd3
    CellAge
    • A homolog of this gene for Homo sapiens is present as HDAC1

    Homologs

    Caenorhabditis elegans
    hda-3
    Caenorhabditis elegans
    hda-1
    Danio rerio
    hdac1
    Danio rerio
    hdac3
    Danio rerio
    hdac8
    Drosophila melanogaster
    Hdac3
    Drosophila melanogaster
    Rpd3
    Homo sapiens
    HDAC2
    Homo sapiens
    HDAC3
    Homo sapiens
    HDAC8
    Homo sapiens
    HDAC1
    Mus musculus
    Hdac1
    Mus musculus
    Hdac8
    Mus musculus
    Hdac2
    Mus musculus
    Hdac3
    Mus musculus
    Gm10093
    Rattus norvegicus
    Hdac1l
    Rattus norvegicus
    Hdac1
    Rattus norvegicus
    Hdac8
    Rattus norvegicus
    Hdac2
    Rattus norvegicus
    Hdac3
    Schizosaccharomyces pombe
    clr6

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 855386
    Homologues
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    UniProt
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    Internet
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